- Rev. William Carlyle, Pastor, 1843-1844
- Rev. John McKittrick, Stated Supply, 1844-1853
- Rev. J. Watt Montgomery, Supply, 1853-1854
- Rev. Robert H. Reid, Supply, 1854-1855
- Rev. E. T. Buist, Stated Supply, 1855-1857
- Rev. T. E. Davis, Supply, 1858-1860
- Rev. E. T. Hyde, Supply, 1861-1863
- Rev. T. E. Smith, Supply, 1864-1865
- Rev. E. F. Hyde, Supply, 1867-1870
- Rev. T. W. White, Stated Supply, 1871-1874
- Licentiate J. Riply Jacobs, Stated Supply, 1875-1876
- Licentiate D. E. Frierson, Supply, 1878-1881
- Licentiate S. E. Bishop, Supply, 1882-1883
- Rev. Robert H. Reid, Stated Supply, 1884-1887
- Rev. Luther Link, Stated Supply, 1887-1888
- Rev. W. L. Boggs, Pastor, 1890-1897
- Rev. A. H. Atkins, Supply, 1898-1901
- Rev. C. A. B. Jennings, Pastor, 1902-1903
- Rev. B. Palmer Reid, Pastor, 1903-1912
- Rev. A. H. Griffith, Pastor, 1913-1916
- Rev. Frank Ligon, Pastor, 1916-1918
- Rev. C. O’N. Martindale, Pastor, 1919-1924
- Rev. W. C. Copeland, Pastor, 1924-1927
- Rev. R. W. Carson, Supply, 1927-1929
- Rev. D. B. Greene, Pastor, 1929-1931
- Rev. P. S. McChesney, Supply, 1932-1934
- Rev. William H. Dendy, Pastor, 1934-1943
- Rev. P. S. McChesney, Pastor, 1943-1952
- Rev. C. R. Terrell, Pastor, 1952-1954
- Rev. Marshall B. Dendy, Pastor, 1955-1969
- Rev. Charles W. Echols, Pastor, 1970-1971
- Rev. John K. Johnston, Supply, 1971-1972
- Rev. Joseph D. Beale, Pastor, 1972-1985
- Mr. Jerry W. Crick, Student Supply, 1987-1991
- Rev. Jerry W. Crick, Pastor, 1991-1993
- Rev. Charles E. Champion, Pastor, 1994-2020
- Dr. Joseph A. Pipa, Jr., Pastor, 2020-Present
- Rev. Zachary G. Groff, Pastor, 2021-Present